UNA is a more experienced institution of agricultural higher education in Nicaragua. During its years of existence, work has been done for a systematic transformation, fulfilling the mission of training professionals and developing research and agricultural extension programs, responding to the different development models that the country has experienced.
On 25 May 1917 by Executive Decree, the National School of Agriculture was established in the Official Journal La Gaceta No. 157 that publicizes the Rules of Procedure of the National School of Agriculture.
On 5 April 1990, Act No. 89, the Autonomy Act of Higher Education Institutions. With this Law, ISCA becomes the current National Agrarian University (UNA), with four faculties: Agronomy (FAGRO); Natural and Environmental Resources (FARENA); Distance Education and Rural Development (FED-DR); and Animal Science (FACA).